洪桂祝

发布时间:2025-03-15

导师简介


个人情况介绍、概览

洪桂祝,女,博士,教授,硕士生导师/博士生导师。比利时安特卫普大学生物化学博士,英国剑桥大学博士后,2017年入选福建省闽江学者,2012年入选福建省“百人计划”,历任英国剑桥大学高级研究员和GlaxoSmithKline剑桥大学Biomarker中心主任。洪桂祝主要针对红景天苷治疗脑卒中及促进脑神经恢复与再生方面的基础研究,主持国家自然科学基金面上项目2项,福建省科技厅重点项目1项,福建省高校产学研项目1项,以通讯作者发表脑卒中相关论文30余篇,申请发明专利4项,授权1项。


人才称号、社会兼职等

福建省第二批“百人计划”,闽江学者讲座教授。


主要研究方向

心脑血管药理和抗炎免疫药理、中药心脑血管药理研究、中药神经精神药理研究


主持、参与的科研项目(含科研获奖等情况)

主持国家自然科学基金面上项目2项(编号:81973503,81473382),福建省科技厅自然科学基金重点项目1项(编号:2021J02014),福建省高校产学研项目1项(编号:2014Y4004)。


近年来发表代表性论文(限第一作者或通讯作者,SCI须写明影响因子)

[1]Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties.European journal of medicinal chemistry.(IF:6.7);

[2]Salidroside Restores an Anti-inflammatory Endothelial

Phenotype by Selectively Inhibiting Endothelial Complement After Oxidative Stress. Inflammation.(IF:5.1);

[3]Salidroside Reduces Inflammation and Brain Injury After Permanent Middle Cerebral Artery Occlusion in Rats by Regulating PI3K/PKB/Nrf2/NFκB Signaling Rather than Complement C3 Activity.Inflammation.(IF:5.1);

[4]Inhibition of Complement Drives Increase in Early Growth Response Proteins and Neuroprotection Mediated by Salidroside After Cerebral Ischemia. Inflammation.(IF:5.1);

[5]Salidroside Inhibits Inflammation Through PI3K/Akt/HIF Signaling After Focal Cerebral Ischemia in Rats. Inflammation.(IF:5.1);

[6]11β-HSD1 modulates LPS-induced innate immune responses in adipocytes by altering expression of PTEN. Molecular endocrinology (Baltimore, Md.)(IF:4.2);

  1. Salidroside-Mediated Neuroprotection is Associated with Induction of Early Growth Response Genes (Egrs) Across a Wide Therapeutic Window. Neurotoxicity research, 28(2),108–121.(IF:3.7)


专利

[1]一种红景天苷衍生物及其制备方法和用途。专利号:ZL 201710786583.9


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